HFpEF patients are more often female, older, more obese, and with lower BNP than patients with HFrEF.
HFpEF patients have more frequent rises of BNP rises and less frequent incidences of weight gain.
Patients with HFpEF demonstrates more day-to-day fluctuations in BNP than patients with HFrEF.
Patients HFpEF and a rapid BNP rise >200 pg/mL in 3 days showed significant association with ADHF.
Future studies investigating separate BNP and weight thresholds in outpatients with HFpEF and HFrEF should be investigated.