Effect of therapeutic interventions on oxidized phospholipids on apolipoprotein B100 and lipoprotein(a)
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- 作者：Calvin Yeang ; MD ; PhDa ; Ming-Yow Hung ; MDb ; c ; d ; Young-Sup Byun ; MDe ; Paul Clopton ; MScf ; Xiaohong Yang ; BSa ; Joseph L. Witztum ; MDg ; Sotirios Tsimikas ; MDa ; stsimikas@ucsd.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Oxidized phospholipids ; Lipoprotein(a) ; Niacin ; Simvastatin ; Ezetimibe ; Statin ; Diet
- 刊名：Journal of Clinical Lipidology
- 出版年：2016
- 出版时间：May-June 2016
- 年：2016
- 卷：10
- 期：3
- 页码：594-603
- 全文大小：746 K
文摘
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Niacin lowers OxPL-apoB in conjunction with Lp(a).
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Ezetimibe/simvastatin increases both OxPL–apoB and Lp(a).
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A systematic review of trials including OxPL-apoB and Lp(a) measurements showed:
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Statin treatment increased OxPL-apoB and Lp(a) levels.
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Lipoprotein apheresis and antisense oligonucleotide to apo(a) lower OxPL-apoB and Lp(a).