Lipoprotein(a)-cholesterol levels estimated by vertical auto profile correlate poorly with Lp(a) mass in hyperlipidemic subjects: Implications for clinical practice interpretation of Lp(a)-mediated risk

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• 作者：Calvin Yeang ; MD ; PhD^a ; Paul C. Clopton ; MS^b ; Sotirios Tsimikas ; MD^a ; ^{stsimikas@ucsd.edu}
• 关键词：Lipoprotein(a) ; Lipoprotein(a)-cholesterol ; VAP ; Oxidized phospholipids ; Niacin ; HDL-Cholesterol
• 刊名：Journal of Clinical Lipidology
• 出版年：2016
• 出版时间：November-December 2016
• 年：2016
• 卷：10
• 期：6
• 页码：1389-1396
• 全文大小：200 K
• 卷排序：10

文摘

Vertical auto profile (VAP)–Lp(a)-C correlates only modestly with Lp(a) mass. VAP-Lp(a)-C rises linearly with HDL-C quartiles, whereas Lp(a) mass does not. VAP may erroneously detect HDL-C when estimating Lp(a)-C due to overlapping densities. A significant number of patients with VAP-Lp(a)-C may have had their Lp(a) risk misclassified. Consideration should be given for repeat measurement of Lp(a) with a validated assay.