Dietary crystalline common-, micro-, nanoscale and emulsified nanoscale sitosterol reduce equally the cholesterol pool in guinea pigs, but varying nanosystems result in different sterol concentrations in serosal jejunum
详细信息 查看全文
- 作者：Gerhard Jahreis ; Steffen Wohlgemuth ; Gregor Gr¨¹nz ; Lena Martin ; Martin Knieling ; Robert Engel ; Michael T¨¹rk ; Sylvia Keller
- 关键词：ACAT ; acyl-CoA cholesterol acyltransferase ; BD ; basal diet ; CCS ; crystalline commonscale sitosterol ; CMLS ; crystalline microscale low sitosterol ; CMS ; crystalline microscale sitosterol ; CNS ; crystalline nanoscale sitosterol ; DM ; dry matter ; ENS ; emulsifie
- 刊名：Nanomedicine: Nanotechnology, Biology and Medicine
- 出版年：2013
- 出版时间：October, 2013
- 年：2013
- 卷：9
- 期：7
- 页码：1027-1035
- 全文大小：934 K
文摘
Due to hypocholesterolemic effects, sitosterol is used in functional foods and nanoscale dispersions. To investigate the influence of dietary sitosterol on sterol concentrations in Dunkin Hartley guinea pigs, seven groups consisting of eight animals each were fed either a basal diet (BD), a high-cholesterol diet (HC) or a high-cholesterol diet supplemented with crystalline commonscale (CCS), microscale (CMS, low-dosed: CMLS), nanoscale (CNS) or emulsified nanoscale (ENS) sitosterol. When compared to HC group, all sitosterol formulations decreased liver cholesterol concentrations. No differences in cholesterol or sitosterol concentration were found in plasma and liver between CCS, CMS, CNS, and ENS groups. Apparent cholesterol digestibility decreased by increasing crystalline microscale sitosterol doses. Despite a lower sitosterol intake, ENS group had higher serosal sitosterol concentrations in jejunum than CNS group. To elucidate an impact of the sitosterol nanosystem on gut tissues further studies are necessary.
From the Clinical Editor
In this study, the use of sitosterols in a rat model led to contradicting conclusions regarding their ability to reduce cholesterol levels efficiently in guinea pigs, suggesting that more preclinical data is needed before this method could become applicable to human studies.