Calcium activated K+ channels in the electroreceptor of the skate confirmed by cloning. Details of subunits and splicing
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- 作者：Benjamin L. Kinga ; Ling Fang Shib ; Peter Kaob ; William T. Clusinb ; wclusin@stanford.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：aa ; amino acid(s) ; BK ; large conductance calcium-activated potassium channel ; cDNA ; complementary DNA ; cSlo ; a version of the Slo gene sequence (an older term for the BK channel α subunit) found in the chicken ; hSlo ; a version of the Slo gene found in humans ; Kcnma1 ; another term for the α subunit of the BK channel ; Kcnmb4 ; β subunit number 4 of the BK channel ; KCNN3 ; one of the sequences for small conductance calcium-activated potassium channels ; mRNA ; messenger RNA ; PCR ; polymerase chain react
- 刊名：Gene
- 出版年：2016
- 出版时间：1 March 2016
- 年：2016
- 卷：578
- 期：1
- 页码：63-73
- 全文大小：2738 K
文摘
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We characterized the BK channel in the skate electroreceptor (ampulla of Lorenzini).
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We cloned and characterized cDNAs for the α and β4 subunit.
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The presence of BK channels in the ampulla is consistent with the known physiology.
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β4 subunits may explain absence of voltage gating of the BK current.
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Our results retrospectively confirm the discovery of a new class of K+ channels.