Molecular characterization of three NPY receptors (Y2, Y5 and Y7) in chickens: Gene structure, tissue expression, promoter identification, and functional analysis
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- 作者：Chen Hea ; 1 ; Jiannan Zhanga ; 1 ; Shunyu Gaoa ; b ; Fengyan Menga ; Guixian Bua ; Juan Lia ; Yajun Wanga ; cdwyjhk@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Chicken ; NPY ; PYY ; PP ; cY2 ; cY5 ; cY7
- 刊名：General and Comparative Endocrinology
- 出版年：2016
- 出版时间：15 September 2016
- 年：2016
- 卷：236
- 期：Complete
- 页码：24-34
- 全文大小：2420 K
文摘
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Chicken NPY receptors (Y2, Y5, Y7) contain novel non-coding exon(s) at their 5′UTR.
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Y2, Y5 and Y7 are widely expressed in chicken tissues including the hypothalamus.
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Y2, Y5 and Y7 expression is driven by their promoter(s) near or upstream exon 1.
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cY2, cY5 and cY7 are preferentially activated by cNPY and cPYY, not by cPP.
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The functional receptors for NPY, PYY and PP peptides are proposed in chickens.