Using hiPSCs to model neuropsychiatric copy number variations (CNVs) has potential to reveal underlying disease mechanisms

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• 作者：Erin K. Flaherty ; Kristen J. Brennand ; ^{kristen.brennand@mssm.edu}
• 关键词：hiPSC ; human induced pluripotent stem cell ; CNV ; Copy number variation ; SNP ; Single nucleotide polymorphism ; PPI ; Paired pulse inhibition
• 刊名：Brain Research
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：1655
• 期：Complete
• 页码：283-293
• 全文大小：1889 K
• 卷排序：1655

文摘

The contribution of copy number variants(CNVs) to schizophrenia genetics. Summary of findings from current mouse models of CNVs. The advantages of using hiPSCs to model CNVs. The potential of hiPSCs in drug discovery, screening and toxicity testing.