Estrogen receptor beta signals to inhibition of cardiac fibrosis
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- 作者：Ali Pedrama ; 1 ; Mahnaz Razandia ; Ramesh Narayananb ; Ellis R. Levina ; c ; ellis.levin@va.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：AMP-Activated kinase (AMPK) ; Estrogen receptor ; Fibrosis ; Angiotensin II
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：15 October 2016
- 年：2016
- 卷：434
- 期：Complete
- 页码：57-68
- 全文大小：2874 K
文摘
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ERβ activated AMP kinase and PKA block AngII-inhibition of Rho and activation of Rho kinase.
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Loss of Rho/Rho kinase markedly decreased TGFβ and CTGF and myofibroblast formation.
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ERβ signaling diminished MMP and collagens I and III production.
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Many of these aspects were confirmed in an in-vivo model of cardiac hypertrophy.