Does neuroinflammation drive the relationship between tau hyperphosphorylation and dementia development following traumatic brain injury?

详细信息    查看全文

• 作者：Lyndsey E. Collins-Praino ^{lyndsey.collins-praino@adelaide.edu.au} ; Frances Corrigan ; ^{frances.corrigan@adelaide.edu.au}
• 关键词：Traumatic brain injury ; Alzheimer&rsquo ; s disease ; Chronic traumatic encephalopathy ; Tau ; Neuroinflammation
• 刊名：Brain, Behavior, and Immunity
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：60
• 期：Complete
• 页码：369-382
• 全文大小：1144 K
• 卷排序：60

文摘

Evidence suggests that sustaining a TBI may predispose to the later development of dementia. The long latency between the TBI and later dementia is an opportunity for treatment. TBI promotes the pathological accumulation of tau. Altered tau dynamics may be exacerbated by a persistent inflammatory response. Timely intervention modulating the immune response may prevent alteration in tau dynamics post-TBI.