A comparative study based on 2-DE followed by LC–MS/MS was performed in skin mucus.
Skin mucus proteome was altered by Pdp11 intake and/or overcrowding stress in S. aurata.
Structural, metabolic, immune and stress proteins were identified.
Pdp11 probiotic promotes the over-expression of most of the proteins in skin mucus.
Lysozyme is up-regulated and over-expressed in skin and skin mucus, respectively.