Comparative Gene Expression Analysis of the Coronal Pulp and Apical Pulp Complex in Human Immature Teeth
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- 作者：Soo-Hyun Kim ; DDS&lowast ; ; Seunghye Kim ; DDS ; PhD&dagger ; ; Yooseok Shin ; DDS ; PhD&Dagger ; ; Hyo-Seol Lee ; DDS ; PhD§ ; ; Mijeong Jeon ; PhD|| ; Seong-Oh Kim ; DDS ; PhD&lowast ; ; Sung-Won Cho ; DDS ; PhD¶ ; ; Nikita B. Ruparel ; DDS ; PhD&lowast ; &lowast ; ; Je Seon Song ; DDS ; PhD&lowast ; ; || ; songjs@yuhs.ac" class="auth_mail" title="E-mail the corresponding author
- 关键词：Apical pulp complex ; complementary DNA microarray ; coronal pulp ; human immature teeth ; immunohistochemical staining
- 刊名：Journal of Endodontics
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：42
- 期：5
- 页码：752-759
- 全文大小：2205 K
文摘
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This study compared the gene expression profiles of human coronal pulp (CP) and the apical pulp complex (APC) with the aim of elucidating whether any differences found can explain differences in their functions.
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The apical papilla and covering follicular tissue were inseparably related to each other and function as a unit.
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The expression levels of genes related to dentin mineralization, neurogenesis, and neurotransmission were higher in the CP in human immature teeth, whereas those of immune-related and tooth development–related genes were higher in the APC.