Novel gold(I) complexes with 5-phenyl-1,3,4-oxadiazole-2-thione and phosphine as potential anticancer and antileishmanial agents

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• 作者：Joana Darc S. Chaves^a ; Luiza Guimarã ; es Tunes^b ; Chris Hebert de J. Franco^a ; Thiago Martins Francisco^c ; Charlane Cimini Corrê ; a^a ; Silvane M.F. Murta^b ; Rubens Lima Monte-Neto^b ; Heveline Silva^d ; Ana Paula S. Fontes^a ; Mauro V. de Almeida^a ; ^{mauro.almeida@ufjf.edu.br}
• 关键词：Gold(I) complexes ; 5-Phenyl-1 ; 3 ; 4-oxadiazole-2-thione ; Antitumor activity ; Antileishmania
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：127
• 期：Complete
• 页码：727-739
• 全文大小：1407 K
• 卷排序：127

文摘

Gold(I) complexes are active against cancer cell lines and Leishmania parasites. Most compounds were more active than cisplatin against B16F10 and CT26.WT cell lines. Compound (6-A) was very selective against colon cancer CT26.WT cell line. Gold(I) complexes can be applied to better understand drug resistance in Leishmania.