Prevention & treatment of obstetrical complications in APS: Is hydroxychloroquine the Holy Grail we are looking for?
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- 作者：Pier Luigi Meronia ; b ; pierluigi.meroni@unimi.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Antiphospholipid syndrome ; Miscarriages ; Antimalarials ; Hydroxychloroquine
- 刊名：Journal of Autoimmunity
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：75
- 期：Complete
- 页码：1-5
- 全文大小：257 K
文摘
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Heparin/low dose aspirin prevent recurrences in obstetric APS, but up to 20% of pregnancies are refractory to this therapy.
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Additional therapies on top of the standard treatment may increase the positive pregnancy outcome.
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Anecdotal reports showed that hydroxychloroquine is beneficial in refractory obstetric APS.
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Experimental models suggest that hydroxychloroquine prevents pathogenic effect of anti-phospholipid antibodies.