A comparative study of venomics of Naja naja from India and Sri Lanka, clinical manifestations and antivenomics of an Indian polyspecific antivenom
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- 作者：Kitisak Sintiprungrata ; 1 ; kitisak@cri.or.th" class="auth_mail" title="E-mail the corresponding author ; Kamolwan Watcharatanyatipa ; 1 ; kamolwan@cri.or.th" class="auth_mail" title="E-mail the corresponding author ; W.D.S.T. Senevirathnec ; 1 ; sandani1983@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Papada Chaisuriyaa ; 1 ; papada@cri.or.th" class="auth_mail" title="E-mail the corresponding author ; Daranee Chokchaichamnankitb ; daranee@cri.or.th" class="auth_mail" title="E-mail the corresponding author ; Chantragan Srisomsapb ; chantragan@cri.or.th" class="auth_mail" title="E-mail the corresponding author ; Kavi Ratanabanangkoona ; c ; kavi.rtn.@mahidol.ac.th" class="auth_mail" title="E-mail the corresponding author
- 关键词：Naja naja India ; Naja naja Sri Lanka ; Venom proteomes ; Geographical variation ; Clinical symptoms ; Antivenomics ; Antibody affinity
- 刊名：Journal of Proteomics
- 出版年：2016
- 出版时间：30 January 2016
- 年：2016
- 卷：132
- 期：Complete
- 页码：131-143
- 全文大小：1094 K
文摘
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Comparative venomics of Naja naja from Indian and Sri Lanka have been carried out.
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Differences in venom protein compositions representing intra-specific variations have been documented.
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The neurotoxin/cytotoxin contents of the venoms explained well the clinical symptoms produced by these venoms.
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Antivenomics study of an Indian antivenom showed lower binding affinity against the Sri Lankan cobra venom proteins.
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The lower antibody binding affinity explained the poor efficacy of the Indian antivenom against Sri Lankan cobra envenoming.