Synthesis, structural characterization, cytotoxicity in vitro, and effect on DNA of sulfate-trans-dichloro-trans-bis(dimethylsulfoxide)-trans-dimethyl-tin(IV)
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- 作者：V铆ctor M. Jim茅nez-P茅rez ; Blanca M. Mu帽oz-Flores ; Alberto G贸mez ; Boris Kharisov ; Rosa Santillan ; Mar铆a E. Ochoa ; Leonor M. Blanco Jerez ; Concepci贸n Garc铆a ; Noem铆 Waksman ; Rosalba Ram铆rez
- 关键词：Organotin ; Sulfate ; X-ray ; DNA interaction
- 刊名：Journal of Molecular Structure
- 出版年：24 January, 2014
- 年：2014
- 卷：1058
- 期：Complete
- 页码：9-13
- 全文大小：722 K
文摘
The trans-dichloro-trans-bis(dimethylsulfoxide)-trans-dimethyl-tin(IV) resulted from the reaction of dimethyl-tin(IV) dichloride and sodium sulfate in dimethylsulfoxide (DMSO). The tin compound was characterized by IR, NMR, FE-SEM, EDS, and single crystal X-ray diffraction studies. Suitable DMSO single crystals were obtained after 7 months by slow evaporation at room temperature. The crystal structure has a polymeric arrangement with eight-membered rings as a result of intermolecular coordination SO 鈫?#xA0;Sn. The tin atom has an octahedral distorted geometry where the DMSO molecule is coordinated, and also has an infinite arrangement in 2D. Cytotoxicity against A431 cancer cells and MOLT4 leukemic cells and the DNA interaction of the organotin compound were determined. The organotin sulfate derivative showed low biological activity because of the polymeric structure and the saturated tin coordination capability.