Bundling potent natural toxin cantharidin within platinum (IV) prodrugs for liposome drug delivery and effective malignant neuroblastoma treatment

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• 作者：Xi Yang ; MD^a ; ¹ ; Jun Tong ; MD ; PhD^b ; ¹ ; Liemei Guo ; MD ; PhD^a ; ¹ ; Zhongrun Qian ; MD^a ; Qixian Chen ; PhD^c ; Ruogu Qi ; PhD^d ; ^{Ruoguqix@gmail.com} ; Yongming Qiu ; MD ; PhD^a ; ^{qiuzhoub@hotmail.com}
• 关键词：Natural toxin ; Liposome ; Picoplatin ; Cantharidin ; Drug delivery ; Neuroblastoma
• 刊名：Nanomedicine: Nanotechnology, Biology and Medicine
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：13
• 期：1
• 页码：287-296
• 全文大小：1469 K
• 卷排序：13

文摘

Neuroblastoma (NB) is one of the most commonly seen malignancies in childhood and infancy. Cantharidin is a highly potent natural toxin that possesses potent anti-tumor properties on various cancers including NB. However, exposure to cantharidin can cause severe chemical burns and application of cantharidin for cancer therapy is limited. Here we report a strategy of bundling cantharidin within a hybrid platinum (IV) prodrug conjugate. This hydrophobic drug conjugate, ie, CanPt can be further formulated into liposome for drug delivery to minimize the exposure of cantharidin to normal cells for efficient chemotherapeutic agent against NB.