Functional magnetic resonance imaging correlates of emotion recognition and voluntary attentional regulation in depression: A generalized psycho-physiological interaction study

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• 作者：Leonardo Tozzi^a ; ^b ; ^c ; ^{tozzil@tcd.ie} ; Kelly Doolin^b ; ^c ; Chloe Farrel^b ; ^c ; Sojo Joseph^c ; Veronica O&rsquo ; Keane^b ; ^c ; Thomas Frodl^a ; ^b ; ^c
• 关键词：FMRI ; Attention ; Depression ; PPI ; Connectivity ; Emotion
• 刊名：Journal of Affective Disorders
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：208
• 期：Complete
• 页码：535-544
• 全文大小：1304 K
• 卷排序：208

文摘

Depressed patients displayed impaired recognition and voluntary regulation of emotion. Across both conditions, they showed hyper-connectivity between and within the default mode and task positive network. During regulation they had less anterior insula response and greater coupling of emotion generation and control areas. Connectivity between the amygdala and visual areas was altered during evaluation of negative and positive pictures. Regulating negative and judging positive pictures they showed less coupling in attentional and emotional regulation areas.