Sex differences in experimental autoimmune encephalomyelitis in multiple murine strains
详细信息 查看全文
- 作者：Papenfuss ; Tracey L. ; Rogers ; Connie J. ; Gienapp ; Ingrid ; Yurrita ; Maria ; McClain ; Melanie ; et. al.
- 关键词：Experimental autoimmune encephalomyelitis ; Multiple sclerosis ; Gender ; Sex ; Sexual dimorphism ; Mouse strains
- 刊名：Journal of Neuroimmunology
- 出版年：2004
- 出版时间：May, 2004
- 年：2004
- 卷：150
- 期：1-2
- 页码：59-69
- 全文大小：462 K
文摘
Multiple sclerosis (MS) is more prevalent in women than men. We evaluated seven different mouse strains commonly used in the study of autoimmune diseases, for sex differences in the disease course of experimental autoimmune encephalomyelitis (EAE). Greater severity of EAE was observed in the female SJL immunized with two different peptides of myelin proteolipid protein (PLP) and myelin oligodendrocyte glycoprotein (MOG) as well as in the female ASW relative to males. Female NZW mice showed a greater incidence of EAE than males. However, male B10.PL and PL/J mice showed more severe disease than females. No sex differences were noted in the C57BL/6 or NOD strains.