The Effects of Nasal Continuous Positive Airway Pressure on Cardiac Function in Premature Infants with Minimal Lung Disease: A Crossover Randomized Trial

详细信息    查看全文

• 作者：Friederike Beker ; MD¹ ; ² ; Sheryle R. Rogerson ; FRACP¹ ; Stuart B. Hooper ; PhD³ ; Connie Wong ; RN¹ ; Peter G. Davis ; MD¹
• 关键词：BP ; Blood pressure ; CO ; Cardiac output ; CPAP ; Continuous positive airway pressure ; CSA ; Cross-sectional area ; HR ; Heart rate ; LPA ; Left pulmonary artery ; LVO ; Left ventricular output ; nCPAP ; Nasal continuous positive airway pressure ; PDA ; Patent ductus arteriosus ; RVO ; Right ventricular output ; SVC ; Superior vena cava ; VTI ; Velocity-time integral
• 刊名：The Journal of Pediatrics
• 出版年：April, 2014
• 年：2014
• 卷：164
• 期：4
• 页码：726-729
• 全文大小：178 K

文摘

| Figures/TablesFigures/Tables | ReferencesReferences

Objective

To assess the effects of different nasal continuous positive airway pressure (nCPAP) pressures on cardiac performance in preterm infants with minimal lung disease, we conducted a randomized, blinded crossover study.

Study design

We studied infants between 28 and 34 weeks' corrected gestational age, treated with nCPAP of 5聽cm H₂O, in air. Infants with significant cardiac shunts were excluded. Infants were randomly assigned to nCPAP levels of 4, 6, and 8 cm H₂O for 15 minutes each. Right and left ventricular outputs and left pulmonary artery and superior vena cava flows were measured 15 minutes after each change.

Results

Thirty-four infants born at a mean gestational age of 29 weeks with a birth weight of 1.3 kg were studied. There were no significant differences in right and left ventricular outputs and left pulmonary artery and superior vena cava flows at different levels of nCPAP.

Conclusion

We investigated the effect of increasing nCPAP levels on cardiac output. We conclude that nCPAP levels between 4 and 8 cm H₂O did not have an effect on cardiac output in stable preterm infants with minimal lung disease.