Comorbid anxiety-like behavior and locus coeruleus impairment in diabetic peripheral neuropathy: A comparative study with the chronic constriction injury model
详细信息 查看全文
- 作者：Cristina Alba-Delgadoa ; b ; cristina.alba@uca.es" class="auth_mail" title="E-mail the corresponding author ; Alberto Cebada-Aleua ; alberto.cebada@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Juan Antonio Micoa ; b ; juanantonio.mico@uda.es" class="auth_mail" title="E-mail the corresponding author ; Esther Berrocosob ; c ; esther.berrocoso@uca.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：CCI ; Chronic Constriction Injury ; ED50 ; Effective Dose 50 ; EZM ; Elevated Zero Maze test ; i.p. ; Intraperitoneal ; i.v. ; Intravenous ; LC ; Locus Coeruleus ; NAT ; Noradrenaline Transporter ; pCREB ; Phospho-cAMP Response Element-Binding protein ; STZ ; Streptozotocin ; TH ; Tyrosine Hydroxylase
- 刊名：Progress in Neuropsychopharmacology & Biological Psychiatry
- 出版年：2016
- 出版时间：3 November 2016
- 年：2016
- 卷：71
- 期：Complete
- 页码：45-56
- 全文大小：1419 K
文摘
- •
Sensorial and affective behaviors, and the LC activity were studied in diabetic rats.
- •
A comparative study with the sciatic nerve constriction (CCI) model was performed.
- •
Anxiety-like phenotype was comorbid with LC alterations at fourth week.
- •
STZ and CCI rat models showed opposed noradrenergic LC alterations.
- •
Specific LC neuroplastic mechanisms are induced depending on the pain model.