WSB-1, a novel IL-21 receptor binding molecule, enhances the maturation of IL-21 receptor

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• 作者：Hidetoshi Nara^a ; Tadashi Onoda^a ; ^b ; Mizanur Rahman^a ; Akemi Araki^a ; Farha Matin Juliana^a ; Nobuyuki Tanaka^c ; ^d ; Hironobu Asao^a ; ^{asao-h@med.id.yamagata-u.ac.jp"" rel=""nofollow}
• 关键词：WSB-1 ; IL-21 receptor ; Glycosylation
• 刊名：Cellular Immunology
• 出版年：2011
• 出版时间：2011
• 年：2011
• 卷：269
• 期：1
• 页码：54-59
• 全文大小：562 K

文摘

Interleukin-21 (IL-21) is a pleiotropic cytokine that regulates T-cell, B-cell, NK-cell, and myeloid-cell functions. IL-21 binds with its cognate receptor complex, which consists of the IL-21 receptor (IL-21R) and the common gamma chain. We identified a novel IL-21R-binding molecule, WSB-1, which contains WD-40 repeats and a SOCS-box domain. WSB-1 associates with the middle part of intracytoplasmic region of IL-21R and enhances the maturation of IL-21R from N-linked glycosylated form to fully glycosylated mature form. Furthermore, WSB-1 moderates IL-21R degradation. Taken together, our present study suggests that WSB-1 has a role in the tuning of the maturation and degradation of IL-21R.