Pro-inflammatory cytokine TNF-α is a key inhibitory factor for lactose synthesis pathway in lactating mammary epithelial cells
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- 作者：Ken Kobayashi ; kkobaya@anim.agr.hokudai.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Chinatsu Kuki ; Shoko Oyama ; Haruto Kumura
- 关键词：α-LA ; α-lactalbumin ; β4Galt ; β-1 ; 4-galactosyltransferase ; DEX ; dexamethasone ; EGF ; epidermal growth factor ; GLUT1 ; glucose transporter 1 ; HK1 ; hexokinase 1 ; LPS ; lipopolysaccharide ; MEC ; mammary epithelial cell ; PBST ; PBS containing 0.05% Tween 20 ; PGM ; phosphoglucomutase ; RT ; reverse transcription ; STAT5 ; signal transducer and activator of transcription 5 ; UGP ; UDP-glucose pyrophosphorylase
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：340
- 期：2
- 页码：295-304
- 全文大小：4768 K
文摘
- 05">
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05">TNF-α causes multiple disruptions of the lactose synthesis pathway in milk-secreting cells.
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TNF-α, IL-1β, and IL-6 influence the lactose synthesis pathway in different manners.
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TNF-α and IL-1β cause degradation of GLUT1 concurrently with activation of NFκB.
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20">TNF-α induces activation of NFκB and inactivation of STAT5 in milk-secreting cells.