Androgen-inducible gene 1 increases the ER Ca2 + content and cell death susceptibility against oxidative stress
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- 作者：Nadine Nickel1 ; Astrid Cleven ; Vitalij Enders ; Dmitrij Lisak ; Lars Schneider ; Axel Methner ; axel.methner@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：AIG1 ; androgen-induced gene 1 ; DMEM ; Dulbecco's Modified Eagle's Medium ; FBS ; fetal bovine serum ; GOSR1 ; Golgi SNAP Receptor Complex Member 1 ; HA ; hemagglutinin ; IRES ; internal ribosomal entry site ; MEFs ; mouse embryonic fibroblasts ; N2a ; Neuro2a ; NFAT ; nuclear factor of activated T cells ; NFIB ; Nuclear Factor 1/B ; PBS-T ; phosphate buffered saline with 0.05% Tween ; RT-PCR ; reverse-transcription polymerase chain reaction ; TMBIM6 ; Transmembrane Bax inhibitor motif containing 6
- 刊名：Gene
- 出版年：2016
- 出版时间：15 July 2016
- 年：2016
- 卷：586
- 期：1
- 页码：62-68
- 全文大小：1066 K
文摘
- 05">
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05">Androgen-induced gene 1 (AIG1) is expressed mainly in the liver, lung and heart.
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AIG1 has three splice isoforms with a tissue-specific expression.
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AIG1 has five transmembrane domains with a luminal N- and cytosolic C-terminus.
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20">AIG1 over-expression slightly increases susceptibility to oxidative stress.
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AIG1 over-expression increases the ER Ca2 + concentration.