Ultradian glucocorticoid exposure directs gene-dependent and tissue-specific mRNA expression patterns in vivo

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• 作者：Charlotte L. George^a ; ^b ; ^{Charlotte.George@imm.ox.ac.uk} ; Matthew T. Birnie^a ; ^{Matthew.Birnie@bristol.ac.uk} ; Benjamin P. Flynn^a ; ^{Ben.Flynn@bristol.ac.uk} ; Yvonne M. Kershaw^a ; ^{Y.Kershaw@bristol.ac.uk} ; Stafford L. Lightman^a ; ^{Stafford.Lightman@bristol.ac.uk} ; Becky L. Conway-Campbell^a ; ^{B.Conway-Campbell@bristol.ac.uk}
• 关键词：Ultradian rhythm ; Glucocorticoids ; GR ; Pituitary ; Prefrontal cortex ; Transcription
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：439
• 期：Complete
• 页码：46-53
• 全文大小：1258 K
• 卷排序：439

文摘

In vivo study of transcriptional decoding of the glucocorticoid ultradian rhythm. Corticosterone pulses elicit gene and tissue-specific mRNA expression patterns. Corticosterone pulses induce pulsatile repression of Pomc hnRNA in rat pituitary. Unlike the PFC, the pituitary exhibits pulsatile Sgk1 mRNA expression levels. Differential GR dynamics underlie tissue-specific transcriptional responsiveness.