Correlation between apparent diffusion coefficient value on diffusion-weighted MR imaging and Gleason score in prostate cancer

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• 作者：X. Wu^a ; ^b ; ^c ; ^{Xingchen.Wu@uta.fi} ; P. Reinikainen^a ; A. Vanhanen^a ; ^d ; M. Kapanen^a ; ^d ; T. Vierikko^b ; P. Ryymin^b ; S. Hyö ; dynmaa^d ; P.-L. Kellokumpu-Lehtinen^a ; ^c
• 关键词：Prostate cancer ; MRI ; Diffusion-weighted imaging ; Apparent diffusion coefficient ; Gleason score
• 刊名：Diagnostic and Interventional Imaging
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：98
• 期：1
• 页码：63-71
• 全文大小：1401 K
• 卷排序：98

文摘

To investigate whether diffusion-weighted imaging (DWI) apparent diffusion coefficient (ADC) correlates with prostate cancer aggressiveness and further to compare the diagnostic performance of ADC and normalized ADC (nADC: normalized to non-tumor tissue).Patients and methodsThirty pre-treatment patients (mean age, 69 years; range: 59–78 years) with prostate cancer underwent magnetic resonance imaging (MRI) examination, including DWI with three b values: 50, 400, and 800 s/mm2. Both ADC and nADC were correlated with the Gleason score obtained through transrectal ultrasound-guided biopsy.ResultsThe tumor minimum ADC (ADCmin: the lowest ADC value within tumor) had an inverse correlation with the Gleason score (r = –0.43, P < 0.05), and it was lower in patients with Gleason score 3 + 4 than in those with Gleason score 3 + 3 (0.54 ± 0.11 × 103 mm2/s vs. 0.64 ± 0.12 × 10−3 mm2/s, P < 0.05). Both the nADCmin and nADCmean correlated with the Gleason score (r = –0.52 and r = –0.55, P < 0.01; respectively), and they were lower in patients with Gleason score 3 + 4 than those with Gleason score 3 + 3 (P < 0.01; respectively). Receiver operating characteristic (ROC) analysis showed that the area under the ROC curve was 0.765, 0.818, or 0.833 for the ADCmin, nADCmin, or nADCmean; respectively, in differentiating between Gleason score 3 + 4 and 3 + 3 tumors.ConclusionTumor ADCmin, nADCmin, and nADCmean are useful markers to predict the aggressiveness of prostate cancer.