Fluorescence spectroscopy and DLS were used to highlight peptide-bile salt interaction.
Antioxidant peptides from milk: LDQW, LQKW and INYW were studied as peptide models.
Self-aggregated peptides were dissociated by bile salt micelles.
Released peptides were likely bound to the surface of bile salt micelles.
INYW could especially interact with bile salts at submicellar concentrations.