Reduced levels of cytosolic DNA sensor AIM2 are associated with impaired cytokine responses in healthy elderly
详细信息 查看全文
- 作者：Qi Wanga ; q.wang01@umcg.nl" class="auth_mail" title="E-mail the corresponding author ; Johanna Westraa ; Johanna.westra@umcg.nl" class="auth_mail" title="E-mail the corresponding author ; Kornelis S.M. van der Geesta ; k.s.m.van.der.geest@umcg.nl" class="auth_mail" title="E-mail the corresponding author ; Jill Moserb ; c ; j.moser@umcg.nl" class="auth_mail" title="E-mail the corresponding author ; Johan Bijzeta ; j.bijzet@umcg.nl" class="auth_mail" title="E-mail the corresponding author ; Timara Kuipera ; t.kuiper@umcg.nl" class="auth_mail" title="E-mail the corresponding author ; Pedro G. Lorencettia ; plorencetti@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Leo A.B. Joostend ; Leo.Joosten@radboudumc.nl" class="auth_mail" title="E-mail the corresponding author ; Mihai G. Netead ; Mihai.Netea@radboudumc.nl" class="auth_mail" title="E-mail the corresponding author ; Peter Heeringac ; p.heeringa@umcg.nl" class="auth_mail" title="E-mail the corresponding author ; Elisabeth Brouwera ; e.brouwer@umcg.nl" class="auth_mail" title="E-mail the corresponding author ; Annemieke M.H. Bootsa ; m.boots@umcg.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：TLRs ; Toll-like receptors ; CLRs ; C-type lectin receptors ; NLRs ; NOD-like receptors ; RLRs ; retinoic-acid-inducible gene-I like receptors ; AIM2 ; absent in melanoma 2 ; WBA ; whole blood assay ; PAMPs ; pathogen-associated molecular patterns ; PRRs ; pattern recognition receptors ; WBC ; whole blood cell ; ESR ; erythrocyte sedimentation rate ; CRP ; C-Reactive Protein ; CMV ; Cytomegalovirus ; pNPP ; p-NitroPhenyl Phosphate ; HP ; healthy participants ; PBMC ; peripheral blood mononuclear cells
- 刊名：Experimental Gerontology
- 出版年：2016
- 出版时间：1 June 2016
- 年：2016
- 卷：78
- 期：Complete
- 页码：39-46
- 全文大小：703 K
文摘
- class="listitem" id="list_l0005">
- class="label">•
Whole blood cytokine responses to PRR ligands were largely similar in young and old.
- class="label">•
Whole blood cytokine responses to poly(dA:dT) were reduced in elderly.
- class="label">•
AIM2 expression and activation were reduced in monocytes of the old.
- class="label">•
Reduced AIM2 sensing with age may be associated with increased infection sensitivity.