Semaphorin signaling in bone
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- 作者：Lieve Verlinden Lieve.Verlinden@med.kuleuven.be" class="auth_mail" title="E-mail the corresponding author ; Dirk Vanderschueren Dirk.Vanderschueren@med.kuleuven.be" class="auth_mail" title="E-mail the corresponding author ; Annemieke Verstuyf ; Mieke.Verstuyf@med.kuleuven.be" class="auth_mail" title="E-mail the corresponding author
- 关键词：Semaphorin ; Plexin ; Neuropilin ; Osteoblast ; Osteoclast
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：5 September 2016
- 年：2016
- 卷：432
- 期：Complete
- 页码：66-74
- 全文大小：702 K
文摘
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Various semaphorin molecules and their neuropilin and plexin receptors are expressed in bone.
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Semaphorins are involved in bone development as well as in the control of normal bone homeostasis.
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Semaphorins affect communication between different cell types by relaying signals in an autocrine or paracrine way.
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Semaphorins target bone resorption as well as formation, making them interesting therapeutic targets.