Click one pot synthesis, spectral analyses, crystal structures, DFT studies and brine shrimp cytotoxicity assay of two newly synthesized 1,4,5-trisubstituted 1,2,3-triazoles
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- 作者：Muhammad Naeem Ahmeda ; aromatics790@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Khawaja Ansar Yasina ; Khurshid Ayubb ; Tariq Mahmoodb ; mahmood@ciit.net.pk" class="auth_mail" title="E-mail the corresponding author ; M. Nawaz Tahirc ; Bilal Ahmad Khana ; Muhammad Hafeeza ; Madiha Ahmedd ; Ihsan ul-Haqd
- 关键词：Click chemistry ; Triazole ; X-ray diffraction ; DFT ; Brine shrimp assay
- 刊名：Journal of Molecular Structure
- 出版年：2016
- 出版时间：15 February 2016
- 年：2016
- 卷：1106
- 期：Complete
- 页码：430-439
- 全文大小：1753 K
文摘
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Triazoles class="boldFont">1 and class="boldFont">2 were synthesized by click one pot three component approach.
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X-ray analysis revealed that geometries are stabilized by non-covalent interactions.
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The spectroscopic results strongly agree with the theoretical studies.
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The Brine shrimp cytotoxicity assay proved that class="boldFont">2 was more potent than class="boldFont">1.