Strategies for the treatment of polymyxin B-resistant Acinetobacter baumannii infections
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- 作者：Thatiany Cevallos Meneguccia ; James Albieroa ; Letí ; cia Busato Migliorinia ; Janio Leal Borges Alvesa ; Giselle Fukita Vianaa ; Josmar Mazuchelia ; Floristher Elaine Carrara-Marronib ; Celso Luiz Cardosoa ; Maria Cristina Bronharo Tognima ; mcbtognim@uem.br" class="auth_mail" title="E-mail the corresponding author ; cristinatognim@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Acinetobacter baumannii ; Resistant ; Polymyxin B ; Antimicrobial combination ; Pharmacodynamic
- 刊名：International Journal of Antimicrobial Agents
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：47
- 期：5
- 页码：380-385
- 全文大小：958 K
文摘
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Synergism of polymyxin B (PMB), fosfomycin (FOF) and meropenem (MEM) in PMB-resistant Acinetobacter baumannii.
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Evaluation of pharmacodynamics of MEM and FOF by Monte Carlo simulation.
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Synergistic activity and reduction of MICs for MEM and FOF allows adequate PTA.
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Proposal of therapeutic schemes for MEM and FOF alone and in combination.
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Pharmacodynamic synergism can assist in treating multidrug-resistant A. baumannii.