111In-DOTA-Annexin V for imaging of apoptosis during HSV1-tk/GCV prodrug activation gene therapy in mice with NG4TL4 sarcoma
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- 作者：Ming-Hsien Lina ; b ; c ; Shih-Yen Wua ; Hsin-Ell Wanga ; Ren-Shyan Liud ; rsliu@vghtpe.gov.tw" class="auth_mail" title="E-mail the corresponding author ; Jyh-Cheng Chena ; jcchen@ym.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：Annexin V ; Apoptosis ; Ganciclovir ; Gene therapy ; Cancer
- 刊名：Applied Radiation and Isotopes
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：108
- 期：Complete
- 页码：1-7
- 全文大小：1327 K
文摘
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Imaging with 111In-DOTA-Annexin V can detect the apoptosis non-invasively.
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This modality is useful clinically to assess disease status and therapeutic response.
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Imaging of cell death will be a unique tool for anti-tumor drug development.