DNA Breaks and End Resection Measured Genome-wide by End Sequencing
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- 作者：Andres Canela1 ; Sriram Sridharan1 ; Nicholas Sciascia1 ; Anthony Tubbs1 ; Paul Meltzer2 ; Barry P. Sleckman3 ; André ; Nussenzweig1 ; andre_nussenzweig@nih.gov" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：1 September 2016
- 年：2016
- 卷：63
- 期：5
- 页码：898-911
- 全文大小：7893 K
文摘
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END-seq provides a high-resolution view of DNA breaks and end resection
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END-seq detects at least one DSB among 10,000 cells not harboring DSBs
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END-seq maps DSBs during antigen receptor rearrangements and genome editing
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END-seq can be used to study DSB formation/repair in various tissues and organisms