Utilization of antiepileptic drugs in Israel

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• 作者：Erez Berman^a ; ^{erezberm@post.bgu.ac.il" class="auth_mail" title="E-mail the corresponding author} ; Eli Marom^a ; ^{ELI.MAROM@MOH.GOV.IL" class="auth_mail" title="E-mail the corresponding author} ; Dana Ekstein^b ; ^{dekstein@hadassah.org.il" class="auth_mail" title="E-mail the corresponding author} ; Ilan Blatt^c ; ^{Ilan.Blatt@sheba.health.gov.il" class="auth_mail" title="E-mail the corresponding author} ; Sara Eyal^d ; ^{sarae@ekmd.huji.ac.il" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Antiepileptic drugs ; Drug utilization ; Drug preparations
• 刊名：Epilepsy & Behavior
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：61
• 期：Complete
• 页码：82-85
• 全文大小：342 K

文摘

The aim of the study was to identify trends in utilization of antiepileptic drugs (AEDs) over time in a nation-wide population in Israel.

Methods

Data on AED utilization (for all indications) for the period 2010–2014 were obtained from pharmaceutical companies that distribute AEDs in Israel. Prevalence of AED utilization was reported as defined daily doses (DDD)/1000 inhabitants/day.

Results

The utilization of most AEDs included in our analysis remained stable over the study period. The greatest increases in utilization of drugs established in Israel were observed for lamotrigine (33%), oxcarbazepine (31%), and primidone (18%). Decreases in use were recorded for carbamazepine (18%) and phenobarbital (15%). Use of older AEDs appeared to be relatively high, compared with the use of newer AEDs.

Conclusions

During the study period of 2010–2014, conventional AEDs remained a main treatment choice in Israel, in certain cases in contrast to current recommendations and guidelines, for reasons yet to be revealed in further research.