Sulfiredoxin inhibitor induces preferential death of cancer cells through reactive oxygen species-mediated mitochondrial damage
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- 作者：Hojin Kima ; 1 ; Gong-Rak Leea ; 1 ; Jiwon Kima ; Jin Young Baekd ; You-Jin Joa ; Seong-Eun Honga ; Sung Hoon Kima ; Jiae Leea ; Hye In Leea ; Song-Kyu Parkb ; Hwan Mook Kimc ; Hwa Jeong Leed ; Tong-Shin Changd ; Sue Goo Rheee ; Ju-Seog Leef ; Woojin Jeonga ; jeongw@ewha.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：BHA ; butylated hydroxyanisol ; DMSO ; dimethyl sulfoxide ; FITC ; fluorescein isothiocyanate ; H2O2 ; hydrogen peroxide ; ΔΨm ; mitochondrial membrane potential ; MPTP ; mitochondrial permeability transition pore ; NAC ; N-acetyl cysteine ; NAO ; nonyl acridine orange ; PO-1 ; Peroxy Orange-1 ; Prxs ; peroxiredoxins ; PBS ; phosphate-buffered saline ; PI ; propidium iodide ; ROS ; reactive oxygen species ; SD ; standard deviation ; Srx ; sulfiredoxin ; Trx ; thioredoxin
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：91
- 期：Complete
- 页码：264-274
- 全文大小：3002 K
文摘
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Srx inhibitor induces the accumulation of sulfinic peroxiredoxins and ROS.
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Srx inhibitor causes the death of cancer cells by oxidative mitochondrial damage.
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Srx inhibitor leads to preferential death of cancer cells over normal cells.
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Srx inhibitor suppresses the growth of xenograft tumors without acute toxicity.
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Targeting Srx might be a novel therapeutic strategy for cancer treatment.