A catalysis study of mesoporous MCM-41 supported Schiff base and CuSO₄·5H₂O in a highly regioselective synthesis of 4-thiazolidinone derivatives from cyclocondensation of mercaptoacetic acid

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• 作者：Hai-Xia Pang^a ; Yong-Hai Hui^a ; ^{hyhai97@126.com" class="auth_mail" title="E-mail the corresponding author} ; Kui Fan^a ; Xue-Jian Xing^a ; Yang Wu^a ; Jing-Hui Yang^a ; Wei Shi^b ; Zheng-Feng Xie^b ; ^{xiezhf@swpu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：MCM-41 ; Schiff base ; Cyclocondensation ; Mercaptoacetic acid ; Catalysis
• 刊名：Chinese Chemical Letters
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：27
• 期：3
• 页码：335-339
• 全文大小：1260 K

文摘

Mesoporous MCM-41 supported Schiff base and CuSO₄·5H₂O shows high catalytic activity in the cyclocondensation of mercaptoacetic acid with imines (or aldehydes and amines) to afford pharmaceutically important thiazolidinone derivatives. The catalytic reactions involving two-components or three-components afforded the desired product in high yields (up to 98% and 99%). Moreover, the catalyst works well with respect to recyclability, giving the product in 85% and 83% yields after recycling six times.