Smurf1 represses TNF-α production through ubiquitination and destabilization of USP5
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- 作者：Guanghui Qiana ; b ; 1 ; Ying Rena ; 1 ; Yibo Zuoa ; Yukang Yuana ; Peng Zhaoa ; Xiaofang Wanga ; Qiao Chenga ; Jin Liua ; Liting Zhanga ; Tingting Guoa ; Chang Liua ; eygjgk@163.com" class="auth_mail" title="E-mail the corresponding author ; Hui Zhenga ; huizheng@suda.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Protein ubiquitination ; Proteasomal degradation ; E3 ligase ; Smurf1 ; USP5
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：3 June 2016
- 年：2016
- 卷：474
- 期：3
- 页码：491-496
- 全文大小：783 K
文摘
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Smurf1 down regulates the protein expression of USP5 in a ligase-activity dependent manner.
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Smurf1 constitutively interacts with USP5.
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Smurf1 down regulates the stability and up regulates the ubiquitination level of USP5.
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Smurf1 inhibits TNFα production through down-regulation of USP5.