Zerumbone attenuates TGF-尾1-mediated epithelial-mesenchymal transition via upregulated E-cadherin expression and downregulated Smad2 signalling pathways in non-small cell lung cancer (A549) cells
详细信息 查看全文
- 作者：You-Cheng Hseua ; b ; Yu-Chi Huangc ; Mallikarjuna Korivic ; Jia-Jiuan Wuc ; Tzong-Der Wayd ; Ting-Tsz Oua ; Li-Wen Chiuc ; Chuan-Chen Leeb ; Meng-Liang Line ; mllinsally@yahoo.com.tw" class="auth_mail" title="E-mail the corresponding author ; Hsin-Ling Yangc ; hlyang@mail.cmu.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：Zerumbone ; EMT ; E-cadherin ; Smad2 ; Metastasis ; Wound-healing
- 刊名：Journal of Functional Foods
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：18
- 期：part_PA
- 页码：58-72
- 全文大小：1787 K
文摘
- class="listitem" id="list_ulist0010">
- class="label">•
Zerumbone attenuates TGF-尾1-mediated EMT in non-small cell lung cancer (A549) cells.
- class="label">•
Zerumbone inhibits TGF-尾1-induced EMT via up-regulation of E-cadherin.
- class="label">•
Zerumbone suppresses TGF-尾1-induced Smad2 expression and transcriptional activity.
- class="label">•
TGF-尾1-mediated metastatic migration and invasion was inhibited by zerumbone.
- class="label">•
Zerumbone may be considered in the development of food-based anticancer drugs for lung cancer.