Defects in muscle branched-chain amino acid oxidation contribute to impaired lipid metabolism
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- 作者：Carles Lerin1 ; 2 ; 3 ; clerin@fsjd.org" class="auth_mail" title="E-mail the corresponding author ; Allison B. Goldfine1 ; 2 ; Tanner Boes1 ; Manway Liu4 ; Simon Kasif4 ; Jonathan M. Dreyfuss1 ; 4 ; Ana Luisa De Sousa-Coelho1 ; 2 ; Grace Daher1 ; Irini Manoli5 ; Justin R. Sysol5 ; Elvira Isganaitis1 ; 2 ; Niels Jessen1 ; Laurie J. Goodyear1 ; Kirk Beebe6 ; Walt Gall6 ; 7 ; Charles P. Venditti5 ; Mary-Elizabeth Patti1 ; 2 ; mary.elizabeth.patti@joslin.harvard.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Insulin sensitivity ; BCAA ; Fatty acid oxidation ; TCA cycle
- 刊名：Molecular Metabolism
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：5
- 期：10
- 页码：926-936
- 全文大小：1343 K
文摘
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Human insulin resistance is associated with perturbed muscle BCAA metabolism.
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Experimental modulation of BCAA metabolic flux alters fatty acid oxidation in vitro.
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Mut heterozygosis leads to increased body weigh and muscle TAG accumulation in mice.