Intralymphatic CCL21 Promotes Tissue Egress of Dendritic Cells through Afferent Lymphatic Vessels
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- 作者：Erica Russo1 ; 5 ; Alvaro Teijeira1 ; 5 ; Kari Vaahtomeri2 ; Ann-Helen Willrodt1 ; Joë ; l S. Bloch1 ; Maximilian Nitschké ; 1 ; Laura Santambrogio3 ; Dontscho Kerjaschki4 ; Michael Sixt2 ; Cornelia Halin1 ; cornelia.halin@pharma.ethz.ch" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：23 February 2016
- 年：2016
- 卷：14
- 期：7
- 页码：1723-1734
- 全文大小：5361 K
文摘
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Downstream-directed DC migration in lymphatic capillaries is lymph flow independent
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Downstream-directed DC migration in lymphatic capillaries is CCL21/CCR7 dependent
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Low flow creates a downstream-oriented CCL21 gradient along lymphatic endothelium
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The flow-induced CCL21 gradient promotes DC trafficking through afferent lymphatics