Induction of immunogenic cell death by radiation-upregulated karyopherin alpha 2 in vitro
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- 作者：Kyung-Hee Songa ; Seung-Youn Junga ; Seong-Mook Kanga ; Mi-Hyoung Kima ; Jiyeon Ahna ; Sang-Gu Hwanga ; Jun-Ho Leeb ; Dae-Seog Limb ; dslim@cha.ac.kr" class="auth_mail" title="E-mail the corresponding author ; Seon Young Namc ; Jie-Young Songa ; immu@kirams.re.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：APC ; antigen-presenting cell ; BMDC ; bone marrow-derived dendritic cell ; CD ; cluster of differentiation ; CTL ; cytotoxic T lymphocyte ; DAMP ; damage-associated molecular pattern ; DC ; dendritic cell ; ICD ; immunogenic cell death ; KPNA2 ; karyopherin alpha 2 ; MHC ; major histocompatibility complex ; RT ; radiation therapy ; SILAC ; stable isotope labeling by amino acids
- 刊名：European Journal of Cell Biology
- 出版年：2016
- 出版时间：June-July 2016
- 年：2016
- 卷：95
- 期：6-7
- 页码：219-227
- 全文大小：1702 K
文摘
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Karyopherin alpha 2 was upregulated by irradiation in HT-29 cells.
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KPNA2 induces the maturation and activation of dendritic cells.
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Immunostimulatory effect of KPNA2 could be beneficial for patients having received radiotherapy.