Karyopherinβ1 regulates proliferation of human glioma cells via Wnt/β-catenin pathway
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- 作者：Ting Lua ; 1 ; Zhen Baob ; 1 ; Yunfeng Wanga ; Lixiang Yanga ; Bing Lua ; Ke Yana ; Shaozhen Wanga ; He Weia ; Zhe Zhangc ; Gang Cuia ; cuigang120@sina.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Human glioma ; KPNB1 ; Wnt/β-Catenin ; Proliferation
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：23 September 2016
- 年：2016
- 卷：478
- 期：3
- 页码：1189-1197
- 全文大小：2970 K
文摘
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KPNB1 accelerated the progress of human glioma via Wnt/β-catenin pathway.
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The decreased β-catenin expression in nucleus of KPNB1-depletion cells.
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We identified the interaction between β-catenin and KPNB1 for the first time.
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The close positive relationship between KPNB1 expression and glioma proliferation.
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Two kinds of glioma cell lines were applied to this study.