1H NMR metabolomics to study the effects of diazepam on anisatin induced convulsive seizures
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- 作者：Pei Lia ; 1 ; Dan-Dan Weia ; 1 ; Jun-Song Wangb ; wang.junsong@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Ming-Hua Yanga ; Ling-Yi Konga ; cpu_lykong@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Diazepam ; Anisatin ; Convulsive seizures ; NMR ; Metabolomics
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：2016
- 出版时间：5 January 2016
- 年：2016
- 卷：117
- 期：Complete
- 页码：184-194
- 全文大小：5620 K
文摘
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Systemic metabolomics study elucidated therapeutic effects and assessed safety of diazepam.
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Anisatin administration produced significant metabolic disturbances and diazepam ameliorated disturbed metabolic mechanism.
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Diazepam relieves mice suffering from the convulsive seizures and has few influence on healthy mice.