New naturally occurring diacetylenic spiroacetal enol ethers from Artemisia selengensis

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• 作者：Kelvin D.G. Wang^a ; Junsong Wang^b ; Sai-Sai Xie^a ; Zhong-Rui Li^a ; Ling-Yi Kong^a ; ^{cpu_lykong@126.com" class="auth_mail" title="E-mail the corresponding author} ; Jun Luo^a ; ^{luojun1981ly@163.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：YVJXNMWEYXCJGE-LBDAHQFJSA-N ; YJUNIMMHDWTLKS-LBDAHQFJSA-N ; GTFWQJQHSKVSMK-YWKSRHQBSA-N
• 刊名：Tetrahedron Letters
• 出版年：2016
• 出版时间：6 January 2016
• 年：2016
• 卷：57
• 期：1
• 页码：32-34
• 全文大小：653 K

文摘

Three new diacetylenic spiroacetal enol ethers, artemiselenols A–C (class="boldFont">1–class="boldFont">3), were isolated from whole plants of Artemisia selengensis Turcz (Compositae). The structures of all compounds were elucidated on the basis of extensive spectroscopic methods and confirmed by the X-ray crystallographic diffraction of class="boldFont">1. Artemiselenol A is a new naturally occurring polyacetylene containing chlorine, and its absolute configuration was determined as 2S, 5S, 6S and 7R by its X-ray crystallographic diffraction, and those of the rest of the compounds were determined by comparison of their CD spectra. All isolates were screened and evaluated for neuroprotection and inhibition of hMAOs.