Acidosis differently modulates the inflammatory program in monocytes and macrophages
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- 作者：Anne Riemanna ; anne.riemann@medizin.uni-halle.de" class="auth_mail" title="E-mail the corresponding author ; Hanna Wuß ; linga ; Harald Loppnowb ; Hang Fub ; Sarah Reimea ; Oliver Thewsa
- 关键词：Acidosis ; Inflammation ; Immune cell function ; Macrophages ; Phagocytosis
- 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：1862
- 期：1
- 页码：72-81
- 全文大小：1248 K
文摘
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Acidosis regulates inflammatory programs depending on immune cell differentiation.
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In macrophages acidosis increases the expression of COX-2 and iNOS.
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This increase is due to p38 activation in murine macrophages by acidosis.
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In macrophages acidosis enhances functional phagocytic activity.
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TNF-α and MCP-1 expression was generally reduced by acidosis.