Drug-in-cyclodextrin-in-liposomes (DCLs) were applied to encapsulate a volatile molecule (anethole).
The HP-β-CD/anethole complex was loaded into Lipoid S100- and Phospholipon 90H-liposomes.
DCLs were prepared using single and double loading techniques.
Nanometric oligolamellar and spherical-shaped vesicles were stable.
Compared to liposomes, DCL improved the encapsulation and photoprotection of anethole.