Interface Contractility between Differently Fated Cells Drives Cell Elimination and Cyst Formation
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- 作者：Christina Bielmeier1 ; 4 ; Silvanus Alt2 ; 3 ; 4 ; Vanessa Weichselberger1 ; Marco La Fortezza1 ; Hartmann Harz1 ; Frank Jü ; licher2 ; Guillaume Salbreux2 ; 3 ; guillaume.salbreux@crick.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Anne-Kathrin Classen1 ; classen@bio.lmu.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：epithelium ; actomyosin contractility ; epithelial cyst ; cell elimination ; tissue patterning ; physical modeling ; continuum mechanics ; vertex model
- 刊名：Current Biology
- 出版年：2016
- 出版时间：7 March 2016
- 年：2016
- 卷：26
- 期：5
- 页码：563-574
- 全文大小：5974 K
文摘
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Different cell fates induce actomyosin contractility at shared cellular interfaces
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Our study implies cell-cluster-size-dependent consequences for tissue integrity
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Single cells are eliminated while intermediate-sized cell clusters form cysts
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Interface contractility may function in tissue homeostasis or tumor initiation