Duplication of the V3 domain in hepatitis C virus (1b) NS5A protein: Clonal analysis and physicochemical properties related to hepatocellular carcinoma occurrence
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- 作者：Odile Petsarisa ; b ; odilepetsaris@yahoo.fr" class="auth_mail" title="E-mail the corresponding author ; Sophie Valleta ; b ; sophie.vallet@chu-brest.fr" class="auth_mail" title="E-mail the corresponding author ; Hé ; lè ; ne Le Guillou-Guillemettec ; heleguillou@chu-angers.fr" class="auth_mail" title="E-mail the corresponding author ; Pascal Veillonc ; paveillon@chu-angers.fr" class="auth_mail" title="E-mail the corresponding author ; Sté ; phanie Gourioub ; stephanie.gouriou@univ-brest.fr" class="auth_mail" title="E-mail the corresponding author ; Georges Barbierd ; georges.barbier@univ-brest.fr" class="auth_mail" title="E-mail the corresponding author ; Jean-Baptiste Nousbaume ; jean-baptiste.nousbaum@chu-brest.fr" class="auth_mail" title="E-mail the corresponding author ; Philippe Saliouf ; philippe.saliou@chu-brest.fr" class="auth_mail" title="E-mail the corresponding author ; Gisè ; le NKontchoug ; gisele.nkontchou@jvr.aphp.fr" class="auth_mail" title="E-mail the corresponding author ; Jean-Claude Trinchetg ; h ; jean-claude.trinchet@jvr.aphp.fr" class="auth_mail" title="E-mail the corresponding author ; Francoise Lunel-Fabianic ; frlunel-fabiani@chu-angers.fr" class="auth_mail" title="E-mail the corresponding author ; Christopher Payana ; b ; christopher.payan@chu-brest.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hepatitis C virus ; NS5A-V3 domain ; Hepatocellular carcinoma ; Duplication ; Genetic variability
- 刊名：Journal of Clinical Virology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：74
- 期：Complete
- 页码：19-25
- 全文大小：1462 K
文摘
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Duplicated HCV-1b NS5A V3 was found in patients with different liver disease outcome.
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By phylogenetic study, V3 DI and V3 DII clonal nucleotide sequences clustered apart.
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By clonal study, HCC V3 DII was genetically more distant from HCV-J than HCC V3 DI.
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These latter were more distant from HCV-J than Ci V3 DII and Ci V3 DI, respectively.
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HCC V3 DII sequences were enriched in hydrophilic and disorder-promoting residues.