A single aspartate mutation in the conserved catalytic site of Rev3L generates a hypomorphic phenotype in vivo and in vitro
详细信息 查看全文
- 作者：Ré ; mi Fritzena ; 1 ; r.fritzen@dundee.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Fré ; dé ; ric Delbosa ; 2 ; Frederic.Delbos@univ-nantes.fr" class="auth_mail" title="E-mail the corresponding author ; Annie De Smeta ; annie.de-smet@inserm.fr" class="auth_mail" title="E-mail the corresponding author ; Benoî ; t Palancadeb ; Benoit.PALANCADE@ijm.fr" class="auth_mail" title="E-mail the corresponding author ; Christine E. Canmanc ; ccanman@umich.edu" class="auth_mail" title="E-mail the corresponding author ; Said Aoufouchid ; Said.AOUFOUCHI@gustaveroussy.fr" class="auth_mail" title="E-mail the corresponding author ; Jean-Claude Weilla ; jean-claude.weill@inserm.fr" class="auth_mail" title="E-mail the corresponding author ; Claude-Agnè ; s Reynauda ; claude-agnes.reynaud@inserm.fr" class="auth_mail" title="E-mail the corresponding author ; Sé ; bastien Storcka ; sebastien.storck@inserm.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：DNA damage ; Rev3l ; DNA polymerase zeta ; Translesion ; Somatic hypermutation
- 刊名：DNA Repair
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：46
- 期：Complete
- 页码：37-46
- 全文大小：1211 K
文摘
- class="listitem" id="list_lis0005">
- class="label">•
Mutation of both Asp of Rev3l catalytic site phenocopies the full knockout.
- class="label">•
Mutation of the first Asp (ATD) is hypomorphic in mouse and in yeast.
- class="label">•
Rev3lATD mice display an altered spectrum of somatic hypermutation at G-C base pairs.