Cohesin Removal along the Chromosome Arms during the First Meiotic Division Depends on a NEK1-PP1γ-WAPL Axis in the Mouse
详细信息 查看全文
- 作者：Miguel A. Brieñ ; o-Enrí ; quez1 ; Stefannie L. Moak1 ; Melissa Toledo1 ; Joshua J. Filter2 ; Stephen Gray1 ; José ; L. Barbero3 ; Paula E. Cohen1 ; 4 ; paula.cohen@cornell.edu" class="auth_mail" title="E-mail the corresponding author ; J. Kim Holloway1 ; jkh44@cornell.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：meiosis ; cohesin ; mouse ; NIMA-like kinase ; WAPL ; prophase pathway
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：18 October 2016
- 年：2016
- 卷：17
- 期：4
- 页码：977-986
- 全文大小：3162 K
文摘
- class="listitem" id="list_ulist0010">
- class="label">•
Loss of NEK1 induces retention of cohesin SMC3 and RAD21L
- class="label">•
Nek1kat2j/kat2j mice show a premature release of WAPL and retention of sororin
- class="label">•
Nek1kat2j/kat2j mice show higher levels of WAPL phosphorylation
- class="label">•
Nek1kat2j/kat2j mice show a reduction of PP1γ protein levels and phosphorylation