CMV-persistence appears to be related to enhanced immunosenescence.
High levels of effector memory CD4 + and CD8 + T cells are related to CMV-persistence.
CMV-seropositive elderly may have lower levels of naïve CD4 + and CD8 + T cells.
Clinical relevance of shifts within the T cell compartment needs investigation.
Standardization regarding identification of T-cell subsets is needed.