Cytomegalovirus persistence and T-cell immunosenescence in people aged fifty and older: A systematic review
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- 作者：Marlies Weltevredea ; marlies.weltevrede@rivm.nl" class="auth_mail" title="E-mail the corresponding author ; Renske Eilersa ; b ; renske.eilers@rivm.nl" class="auth_mail" title="E-mail the corresponding author ; r.eilers@umcg.nl" class="auth_mail" title="E-mail the corresponding author ; Hester E. de Melkera ; hester.de.melker@rivm.nl" class="auth_mail" title="E-mail the corresponding author ; Debbie van Baarlec ; debbie.van.baarle@rivm.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：CM ; Central Memory ; EM ; Effector Memory ; IRP ; Immune Risk Profile ; TEMRA ; Effector Memory T cell Re-expressing CD45RA
- 刊名：Experimental Gerontology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：77
- 期：Complete
- 页码：87-95
- 全文大小：755 K
文摘
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CMV-persistence appears to be related to enhanced immunosenescence.
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High levels of effector memory CD4 + and CD8 + T cells are related to CMV-persistence.
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CMV-seropositive elderly may have lower levels of naïve CD4 + and CD8 + T cells.
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Clinical relevance of shifts within the T cell compartment needs investigation.
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Standardization regarding identification of T-cell subsets is needed.